Scientist Profile
















Details of Research Publications (National + International)

Author Names Topic Journal Name Volume Number Issue Number Page Number Year Published Impact Factor
Gage M, Yuldasheva N, Viswambharan H, Sukumar P, Cubbon R, Imrie H, Abbas A, Smith J, Kahn M, Wheatcroft SB & Kearney MTEndothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species. Atherosclerosis2301131-1392013
Sukumar P, Viswambharan H, Imrie H, Cubbon RM, Yuldeshava N,Gage M, Galloway S, Skromna A , Kandavelu P, Santos C-X, Gatenby VK, Smith J, Beech DJ, Wheatcroft SB, Channon KM, Shah AM & Kearney MT.Role of NADPH oxidase in endothelial dysfunctionDiabetes6262130-21342013
Imrie H, Viswambharan H, Sukumar P, Abbas, A, Cubbon RM, Yuldeshava N, Gage M, Smith J, Galloway S, Skromna A, Rashid ST, Futers S, Xuan S, Gatenby VK, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB & Kearney MTNovel Role of the IGF-1 receptor in endothelial cell function and repair: studies in endothelium-targeted IGF-1R transgenic mice.Diabetes6192359-23682012
Sukumar P, Sedo A, Li J, Wilson LA, O'Regan D, Lippiat JD, Porter KE, Kearney MT, Ainscough JF & Beech DJConstitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.Circulation Research1112191-2002012
Rajwani A, Ezzat V, Smith J, Yuldasheva N, Duncan N, Gage M, Cubbon RM, Kahn MB, Imrie H, Abbas A, Viswambharan H, Aziz A,Sukumar P, Vidal-Puig A, Sethi JK, Xuan S, Shah AM, Grant PJ, Porter KE, Kearney MT & Wheatcroft SBIncreasing circulating IGFBP1 levels improves insulin-sensitivity, promotes nitric oxide production, lowers blood pressure and protects against atherosclerosis.Diabetes614915-9242012
Abbas A, Imrie H, Viswambharan H, Sukumar P, Rajwani A, Cubbon RM, Gage M, Smith J, Galloway S, Yuldeshava N, Kahn M, Xuan S, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB & Kearney MTThe insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.Diabetes6082169-21782011
Majeed Y, Bahnasi Y, Seymour VA, Wilson LA, Milligan CJ, Agarwal AK, Sukumar P, Naylor J & Beech DJRapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels.Molecular Pharmacology7961023-10302011
Kahn MB, Yuldasheva NY, Cubbon RM, Smith J, Rashid ST, Viswambharan H, Imrie H, Abbas A, Rajwani A, Baliga V, Sukumar P, Gage M, Kearney MT & Wheatcroft SBInsulin resistance impairs circulating angiogenic progenitor cell function & delays endothelial regeneration.Diabetes6041295-13032011
Cheong A, Li J, Sukumar P, Kumar B, Zeng F, Riches K, Munsch C, Wood IC, Porter KE & Beech DJ.Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers.Cardiovascular Research892282-2892011
Ciurtin C, Majeed Y, Naylor J, Sukumar P, English AA, Emery P & Beech DJTRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan. BMC Musculoskeletal Disorders111112010
Wong CO, *Sukumar P, Beech DJ & Yao XNitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflugers Archive4601121-1302010
Naylor J, Li J, Milligan CJ, Zeng F, Sukumar P, Hou B, Sedo A, Yuldasheva N, Majeed Y, Beri D, Jiang S, Seymour VA, McKeown L, Kumar B, Harteneck C, O'Regan D, Wheatcroft SB, Kearney MT, Jones C, Porter KE & Beech DJPregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.Circulation Research10691507-15152010
Sukumar P & Beech DJStimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+).Biochemical and Biophysical Research Communications393150-542010
Milligan CJ, Li J., Sukumar P, Majeed Y, Dallas M, English A, Emery P, Porter KE, Smith AM, McFadzean I, Beccano-Kelly D, Bahnasi YM, Cheong A, Naylor J, Zeng F, Liu X, Gamper N, Jiang LH, Pearson HA, Peers C, Robertson B & Beech DJRobotic multi-well planar patch-clamp for native and primary mammalian cells.Nature Protocols42244-2552009
Li J, Sukumar P, Milligan CJ, Kumar B, Ma Z, Munsch CM, Jiang LH, Porter KE & Beech DJInteractions, functions and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circulation Research103897-1042008
Xu SZ, *Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, AL-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A & Beech DJ.TRP channel activation by extracellular thioredoxin.Nature45169-722008
Beech DJ & Sukumar PChannel regulation by extracellular redox protein. Channels16400-4032007
Xu SZ, *Muraki K, *Zeng F, *Li J, *Sukumar P, Shah S, Dedman A.M, Flemming PK, Naylor J, Cheong A, Bateson AN, Porter KE, Munsch CM & Beech DJA sphingosine-1-phosphate activated calcium channel controlling vascular smooth muscle cell motility.Circulation Research98111381-13892006
Kumar B, Dreja K, Shah S, Cheong A, Xu S.Z, Sukumar P, Naylor J, Forte A, Cipollaro M, McHugh D, Kingston P, Heagerty AM, Munsch CM, Bergdahl A, Hultgardh-Nilsson A, Gomez MF, Porter KE, Hellstrand P, & Beech DJUp-regulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia.Circulation Research984557-5632006
Cheong A, Bingham AJ, Li J, Kumar B, Sukumar P, Munsch CM, Buckley NJ, Neylon CB, Porter KE, Beech DJ & Wood I.CDown-regulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation.Molecular Cell2045-522005

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